Clinical application of CRISPR-Cas9 technology for large deletions of somatic mutations is inefficient, and methods to improve utility suffer from our inability to rapidly assess mono- vs.biallelic deletions.Here we establish a model system for investigating allelic heterogeneity at the single-cell level and identify indel scarring from non-simulta
People with visual impairments often face difficulties in determining the authenticity of SEABUCKTHORN BERRY LOTION paper money, which is a crucial skill to avoid fraud.The limitations of traditional methods, like blind codes for visually impaired people, require a more advanced and efficient solution.Previous methods of currency detection using Co
Abstract Background Post-translational modification of lysine residues of specific proteins by ubiquitin modulates the degradation, localization, and activity of these target proteins.Here, we identified gains of ubiquitylation sites in highly conserved regions of human proteins that occurred during human evolution.Results We analyzed Ski de fond -